Another cardiovascular risk factor is arterial hypertension (AH), and Capsaicin can interfere in its etiopathogenesis, releasing vasodilator neuropeptides through TRPV1 activation, inhibiting L-type Ca2+ channels in smooth muscle cells, stimulating natriuresis and diuresis, and inhibiting the angiotensin-converting-enzyme (ACE). This evidence concerns the gene ACE and Hypertension.