Furthermore, the negative correlation between systemic levels of albumin and creatinine, in association with the positive correlation between albumin levels and estimated creatinine clearance, corroborates the proposal that albumin is a biomarker of healthy aging, given that, as previously mentioned, increased serum creatinine levels can indicate not only the development of cardiovascular diseases [45] but also renal disruptions. This evidence concerns the gene ALB and cardiovascular disorder.