The latest knowledge on the molecules related to the immune system and the CNS that shape neuroplasticity in MS relates to the brain-derived neurotrophic factor (BDNF), interleukin 1β, amyloid-β-1-42, platelet-derived growth factor (PDGF) and the cannabinoid receptor type 1 (CB1Rs) and others [11]. The gene discussed is BDNF; the disease is myeloid sarcoma.