Therefore, some “dark genes” related to the prognosis of PAAD may play important roles in the development of T2DM, such as COL1A1, which is the most significant gene in the extracellular matrix receptor interaction pathway and is linked to hypoglycemic activity [43], which may affect blood glucose fluctuations, T2DM prognosis, and the occurrence and development of chronic complications [44]. This evidence concerns the gene COL1A1 and pancreatic adenocarcinoma.