SIRT1 and obesity due to melanocortin 4 receptor deficiency: Furthermore, it has also been reported that the combination of quercetin and resveratrol reversed the HFD-induced inhibition of 5’-adenosine monophosphate activated protein kinase α1 (AMPKα1) phosphorylation and sirtuin 1 (SIRT1) expression in the epididyotic adipose tissue of mice, suggesting that the combination may inhibit obesity and associated inflammation in rats fed with an HFD through the AMPKα1/SIRT1 signaling pathway [125].