IL-17A, IL-17B, IL-17C, as well as IL-17F have been shown to promote tumor development, whereas IL-17D and IL-17E play anti-cancer roles in a context-dependent manner by activating the Nrf2 stress surveillance pathway, recruiting innate immune cells, and activating leukocytes [67,159,193,194,195]. The gene discussed is IL17C; the disease is neoplasm.