At the same time, the production of anti-tumor IFN-γ by γδ T cells is reduced; (2) hypercholesteremia induces higher levels of IL-17 in the serum and promotes tumor growth; (3) obesity disrupts IL-17-mediated regulation on intestinal microbiota, which results in glucose intolerance and insulin resistance, which are also linked to increased risk in cancer development. The gene discussed is IFNG; the disease is obesity due to melanocortin 4 receptor deficiency.