AKT1 and breast cancer: The 3144 DE mRNAs were related to 340 KEGG pathways (Table S3B); the top 20 significantly enriched pathways are shown in Figure 4B. The most prevalent pathways associated with DE mRNAs were associated with ECM-receptor interaction, the PI3K-Akt signaling pathway, breast cancer, complement and coagulation cascades, protein digestion and absorption, and arachidonic acid metabolism.