Therefore, we analyzed the expression of genes associated with cancer progression and metabolism, TWIST1, SNAI1, NR5A2, MYC, CXCR2, STK11, POU5F1 (OCT4, isoforms A, B, and B1), HMGA2, as well as miR-205-5p, in the matched samples of tumor-adjacent tissues and tumors from patients with endometrial cancer, and in the samples of endometrium from patients with uterine leiomyoma. The gene discussed is HMGA2; the disease is cancer.