Among the single-nucleotide polymorphisms (SNPs) associated with AD risk, two SNPs have implicated the Abelson-interactor family member 3 (ABI3) gene, including a rare missense SNP (rs616338) within ABI3 exon 5 and a common SNP (rs28394864) located 150,000 bp downstream of ABI3 [2,3,4,5]. Here, ABI3 is linked to Alzheimer disease.