CKLF and Genetic 46,XY disorder of sex development: Other such genes are CMTM3, a member of the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) [85], AKAP8, a member of a-kinase anchoring proteins (AKAPs) [86] and HSD17B14, as hydroxysteroid (17-beta) dehydrogenase (HSD17B) gene family has a role in steroid hormone biosynthesis and deficiencies in such genes can even lead to sex development disorders [87].