The upregulation of Cyp11b2 in the hypothalamus of ISIAH rats, which has previously been confirmed by qPCR [33], suggests that the excessive aldosterone synthesis in the hypothalamus of ISIAH rats may contribute to the pathogenesis of stress-sensitive hypertension and to the observed changes in behavior linked with increased anxiety in ISIAH rats. The gene discussed is CYP11B2; the disease is Anxiety.