Due to RasGRP3 being expressed in endothelial cells and related to a variety of diseases, and the fact that this study found that the expression of RasGRP3 in endothelial cells of ECA was different from normal, we speculated that RasGRP3 was involved in coronary atherosclerosis, but this has not been reported so far. The gene discussed is RASGRP3; the disease is coronary atherosclerosis.