Although the specific role of SF3B1 mutations in MDS-RS is not curtained, downregulation of ABC, upregulation of ALAS2, and downregulation of ABCB7 have been reported in refractory anemia with ring sideroblasts (RARS), the term previously used for MDS-RS [131,132]. Here, SF3B1 is linked to myelodysplastic syndrome.