Indeed, The Breast Cancer Association Consortium [82] interrogated rare germline variation of nine genes including ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, RAD51D and TP53 across 42,580 BC patients and 46,387 control subjects independent of family history of disease. Here, CHEK2 is linked to breast cancer.