Indeed, The Breast Cancer Association Consortium [82] interrogated rare germline variation of nine genes including ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, RAD51D and TP53 across 42,580 BC patients and 46,387 control subjects independent of family history of disease. The gene discussed is PALB2; the disease is breast cancer.