Since the function of PROZ in HCC is still unclear, we further analyzed the signaling pathways that PROZ may affect in the TCGA database, and the GO analysis revealed that PROZ co-expressed genes were mainly related to the organic acid catabolic process, fatty-acid metabolic process, mitochondrial matrix, pyridoxal phosphate binding, and so on (Figure 4A). Here, PROZ is linked to hepatocellular carcinoma.