Furthermore, the combined CT+TT allele was also in linear correlation (p < 0.05) with high blood glucose and HbA1c levels in overall subjects and female individuals, while in male individuals the effect of klotho gene C1818T polymorphism on fasting blood glucose and HbA1c levels was non-significant (p > 0.05), which indicates that individuals with the TT genotype are more prone to hyperglycemia and high glycated hemoglobin. This evidence concerns the gene KL and Hyperglycemia.