Furthermore, recent studies have shown that missense mutations in the arginine/serine (RS) domain—particularly within a conserved RSRSP stretch—of RBM20 also lead to aberrant splicing and severe DCM in patients and animal models [17,18,19,20,21,22,23,24,25,26]. The gene discussed is RBM20; the disease is familial dilated cardiomyopathy.