The first five have autosomal dominant inheritance, while variants in the SLC26A2 gene cause the autosomal recessive form (rMED or MED type 4) (OMIM: 226900), which demonstrates the milder clinical form within the spectrum of SLC26A2-associated skeletal dysplasia [1,5]. The gene discussed is SLC26A2; the disease is multiple epiphyseal dysplasia type 4.