IMPG1-associated VMD patients also present with subretinal material accumulation above the RPE at any stage of the macular dystrophy [13], whereas it should be noted that in the juvenile VMD, Best disease, associated with BEST1 mutations, the deposits are localized between the RPE and its underlying basement membrane, the Bruch’s membrane [23]. The gene discussed is IMPG1; the disease is Macular dystrophy.