TMPRSS6 has been described as associated with a type of iron deficiency anaemia (IDA), a condition termed iron-refractory iron deficiency anaemia (IRIDA), which presents highly variable haemoglobin (Hb) levels and mean corpuscular volume (MCV) resulting in microcytic hypochromic anaemia and the iron parameters presents a low transferrin saturation, whereas serum ferritin level is normal and hepcidin is high [3,4,5]. The gene discussed is HAMP; the disease is IRIDA syndrome.