We observed that the PAPP-A level measured in the first trimester, albumin levels, eGFR, total bilirubin levels measured near delivery, and placental syncytial knot status were associated with the severity of pregnancy-related hypertensive disorders in addition to blood pressure or liver or kidney function, among which albumin levels and increased placental syncytial knots showed a significant association. The gene discussed is ALB; the disease is hypertensive disorder.