Here, HIES including STAT3 deficiency and STAT3-related deficiency is also associated with activated Th2 responses and decreased Th17 generations; CARD11 deficiency, IPEX syndrome, STAT5B deficiency, and OS affect Treg diversity or function that regulates Th2 immunity. This evidence concerns the gene STAT5B and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.