IGHE and Eczematoid dermatitis: K. Felgentreff et al. reported in 2014 that patients with heterozygous mutations in TGFBR1 and TGFBR2 presented with immune dysregulation resembling STAT3-HIES, including highly elevated IgE, severe eczema, recurrent respiratory infections, skeletal and connective tissue abnormalities [20].