ARMC5 and Cushing syndrome due to macronodular adrenal hyperplasia: Moreover, recent studies reported that the inactivating variants in the ARMC5 (Amadilo repeats containing 5; OMIM 615,549) gene located on chromosome 16p11.2 are the most common genetic cause of PBMAH (primary bilateral macronodular adrenal hyperplasia), which is a rare type of Cushing syndrome characterized by the bilateral enlargement of the adrenal glands, large adrenal nodules (>10 mm), and increased cortisol production.