Unfortunately, because the CXCR4-targeted therapies do not only eradicate the CXCR4-expressing malignant cells but also the haematopoietic stem and progenitor cell niche within the bone marrow, haematological toxicity is the most commonly encountered side effect, which often results in fatal neutropenic sepsis [124]. This evidence concerns the gene CXCR4 and Sepsis.