CXCR4 is overexpressed in more than 30 types of human cancer, including uterine carcinosarcoma, lung squamous cell carcinoma, colorectal adenocarcinoma, pancreatic adenocarcinoma, bladder urothelial carcinoma, lung adenocarcinoma, breast cancer, melanoma and lymphoid neoplasms such as diffuse large B-cell lymphoma among others [13]. The gene discussed is CXCR4; the disease is melanoma.