For an example, Vag et al. reported that although CXCR4 positivity was seen in vitro in most solid malignancies, including pancreatic carcinoma, laryngeal carcinoma, hepatocellular carcinoma, melanoma, breast cancer, glioblastoma and sarcoma, only low to moderate 68Ga-Pentixafor positivity was noted on PET/CT imaging [27]. This evidence concerns the gene CXCR4 and hepatocellular carcinoma.