NFKB1 and breast carcinoma: Concerning NF-kB signaling, often activated in inflammation-related cancers, it may repress miR-29a/b1 promoter activity directly in several tumors, as in breast cancer [32,34], or indirectly, by activating the transcription suppressor Yin Yang 1 (YY1), as in rhabdomyosarcoma [35].