An example of how the indirect activity of miR-29b on methylation status may promote tumor features was revealed in MDA-MB-231 and MCF7 cells, in which it has been demonstrated that miR-29b can directly target the 3′UTR region of TET1, in turn responsible for direct binding with the promoter region of the EMT-related transcription factor ZEB2 [68]. The gene discussed is ZEB2; the disease is neoplasm.