In colon cancer, ADAM17 protein is overexpressed in primary and metastatic tumors compared with normal colonic mucosa and the intensity of its immunoreactivity is inversely correlated with that of TGF-alpha and amphiregulin [49], with ADAM17 gene expression significantly higher in liver metastases than in primary tumors [50]. The gene discussed is AREG; the disease is metastatic neoplasm.