As shown in Figure 2, the 5-year and 10-year cumulative incidence of HCC development were 0% and 6.6%, respectively, in patients with age <50 years and AFP <8 ng/mL; and 15.4% and 32%, respectively, in patients with age ≥50 years and AFP ≥8 ng/mL. This evidence concerns the gene AFP and hepatocellular carcinoma.