AFP and hepatocellular carcinoma: The results of the multivariate Cox regression analysis showed a treatment age ≥50 years (HR: 2.34, 95% CI = 1.08–5.1) and an AFP ≥8 ng/mL (HR: 2.05, 95% CI = 1.1–3.84) were significant independent predictors of HCC development during NUC treatment (Table 2).