Given the fact that there is a high demand for new biomarkers to improve individualized treatment regimens and prediction outcomes due to breast cancer heterogeneity and that TUBB is overexpressed in diverse tumors and plays a vital role in carcinogenesis [8,9,13], the aim of this report is to predict the significance of TUBB in ERα-positive versus ERα-negative breast cancer by bioinformatics analyses of databases. The gene discussed is TUBB; the disease is breast carcinoma.