Given that the mTOR pathway regulates the differentiation and function of T and B cells [33,34] and that significant positive correlations were observed between TUBB and several gene markers of B and T cells in ERα-positive breast cancer, these findings agree with our previous observation that TUBB might be more involved in the activation of the TSC/mTOR pathway in ERα-positive breast cancer compared to ERα-negative breast cancer. Here, TUBB is linked to breast cancer.