Mutations of chromatin remodeling genes in telomeric regions (ATRX) are less common in DIPG than supratentorial HGG, showing ATRX mutations, commonly mutated in almost all H3.3 G34-mutant gliomas, and only in a slow percentage of H3.1 mutated DIPG (about 9%). This evidence concerns the gene ATRX and central nervous system cancer.