In 2011, Paugh et al. subclassified DIPG into three subgroups, based on the most recurrent genetic alteration, a PDGFRA alteration found in 47% of DIPGs, a RB amplification in another 31% of samples, and the third part with both pathways involved [21]. The gene discussed is PDGFRA; the disease is diffuse intrinsic pontine glioma.