IGHE and allergic disease: Humanised IgE reporter systems have been used to elucidate an intriguing ‘outbreak’ of allergy to wheat hydrolysate containing cosmetic products in Japan [12,13], for the assessment of potential allergenicity of anti-helminthic vaccine candidates [14], to identify exposure to Ascaris lumbricoides as a potential cause underlying red meat allergy (Alpha-Gal sensitisation) [15] or to identify potential new allergens in black tiger shrimps [16], with another group suggesting that they may be superior to conventional diagnostic allergy tests in the case of shrimp allergy [17].