The investigational anti-IL-4Rα inhibitor AZD1402, the anti-IL-5 mAb depemokimab, the anti-IL-17A mAb CJM112, the anti-TSLP mAb ecleralimab, the ENaC inhibitor BI 443651, the MABA CHF6366, and the anti-Fel d 1 mAb REGN1908-1909 were proven effective in the treatment of asthma, although data almost exclusively regarded the assessment of lung function, and thus did not allow conclusions regarding symptoms control and the secondary endpoints of this systematic review. The gene discussed is IL4R; the disease is asthma.