In the early 2000s, the introduction of biological therapies directed towards specific inflammatory pathways advanced the improvement of asthma outcomes, initially with the anti-IgE monoclonal antibody (mAb) omalizumab [9], followed 10 years later by the approval of the mAbs anti-interleukin (IL)-5 mepolizumab and reslizumab, and the anti-IL-5Rα benralizumab [10]. The gene discussed is IGHE; the disease is asthma.