In rat basilar arteries of 2-kidney, 2-clip (2K2C) renal hypertensive rats, exogenously applied angiotensin II (Ang II) induced vasoconstriction that was sensitive to T16Ainh-A01, and Ang II evoked TMEM16A-mediated CaCC currents in rat basilar smooth muscle cells [59]. The gene discussed is ANO1; the disease is hypertensive disorder.