As Ang II decreased TMEM16A expression in some vascular smooth muscle cells, including those from rat basilar arteries [59,60,63], an increase in vascular Ang II concentration in the basilar arteries of 2K2C renal hypertensive rats might downregulate TMEM16A expression and hence reduce the CaCCs’ current in this model. The gene discussed is ANO1; the disease is Hypertension.