The association between sDPP4, obesity, and the extension of VAT mass was also reported in adolescents [125], where DPP4 levels negatively correlated with basal and oral glucose tolerance test (OGTT)-stimulated GLP-1 secretion, confirming the relationship between higher sDPP4 levels and its increased enzymatic activity [125]. Here, DPP4 is linked to obesity due to melanocortin 4 receptor deficiency.