SLC8A1 and chronic kidney disease: Interestingly, the decreases in cardiac expression of both SERCA2a and NCX-1, as well as the echocardiographic and histologic phenotype, mirror the molecular, structural, and functional phenotype seen in other models of CKD, including 5/6 nephrectomy [48,49,50], which suggests that the high-salt diet-induced renal disease model may share a common phenotype with other CKD models of uremic cardiomyopathy.