First, the presence of PML bodies was confirmed in all HL cell lines, and observed in both mononucleated Hodgkin’s (H) cells and multinucleated Reed–Sternberg (RS) cells as shown in Figure 2A. The presence of the phosphorylated form of the telomeric repeat-binding factor 1 (pT371-TRF1) was also confirmed in all HL cell lines, in both H and RS cells, as shown in Figure 2B. In addition, colocalization of pT371-TRF1 and PML bodies was observed in all HL cell lines (Figure 2C and Appendix A, Figure A2), suggesting the presence of APBs, hallmarks of ALT, in all HL cell lines. This evidence concerns the gene TERF1 and Hodgkins lymphoma.