Given the increased expression of MyBP-H in ALS muscle, they investigated whether the downstream ROCK pathway was also affected: surprisingly, even though they detected an increased expression of ROCK in the muscle, the downstream signaling was impaired; indeed, treatment with lambda phosphatase revealed the accumulation of a non-phosphorylated LIMK1 in ALS patients. The gene discussed is MYBPH; the disease is amyotrophic lateral sclerosis.