ARHGDIA and Alzheimer disease: Again in the context of AD, the proteomics analysis of mitochondria isolated from peripheral blood lymphocytes has highlighted several proteins altered between controls and AD patients, grouped into four categories: (i) cellular energetics, including GADPH, LDH B-chain, and ATP synthase subunit beta; (ii) structural proteins, including annexin, beta-centractin, and myosin light polypeptide 6; (iii) cell signaling, including Rho GDP-dissociation inhibitor 2 (RhoGDI); and (iv) cellular defense, including thioredoxin-dependent peroxide reductase/peroxiredoxin III (PDXIII) [87].