CPLX1 and Parkinson disease: In a pioneering paper, Basso and co-workers compared protein extract from the substantia nigra of PD patients and controls, and identified forty-four proteins expressed in this mid-brain region by peptide mass fingerprinting, among which, nine showed changes in their abundance: L and M neurofilament chains were less abundant in PD, whereas peroxiredoxin II, mitochondrial complex III, the ATP synthase D-chain, complexin I, profilin, the L-type calcium channel delta-subunit, and the fatty-acid binding protein were more present in PD samples than controls [93].