The characterization of other Calabrian families and subjects also allowed us to identify other novel mutations or variants associated with FTD, MAPT Val75Ala [34], V363I [35], IVS10 + 4A > C and IVS9 − 15T > C [36], and GRN Cys139Arg [32] and Cys139Arg [33], and in genes not generally associated with FTD such as PRNP P39L [37], PSEN2 Arg62His [34], and PSEN1 Val412Ile [36] (Table 1). Here, PSEN2 is linked to frontotemporal dementia.