In addition, this study allowed us to identify three novel missense variations of the LRRK2 gene (p.Phe1227Leu, p.Gly1520Ala, and p.Ile2020Ser) associated with PD in Calabrian patients, underlying, once again, the peculiar genetic characteristics of this population and providing additional genetic insight into PD [11] (Table 1). Here, LRRK2 is linked to Parkinson disease.