Through the raised triose phosphate concentrations generated by glycolysis, hyperglycemia stimulates de novo synthesis of the lipid second messenger diacylglycerol (DAG) responsible for the hyperactivation of several protein kinase C (PKC) isoforms (β, δ, and θ), which contributes to coronary endothelial dysfunction in diabetes [41]. This evidence concerns the gene PRRT2 and diabetes mellitus.