This approach led to the detection of 159 proteins, of which 10 over-expressed in GDM placental tissue and 9 under expressed compared to normal placenta: Periostin, Ig gamma-2 chain C region, CSH, Moesin, Heat-shock-related 70 kDa protein 2, triosephospate isomerase, Protein disulfide-isomerase, Galectin-1, Vimentin, 14-3-3 protein beta/alpha. This evidence concerns the gene LGALS1 and gestational diabetes.