The autophagy-modulating effects of β-caryophyllene in cancer cells have been scantily investigated; a possible switch of autophagy to apoptosis has been hypothesized by Irrera et al. [88], since the sesquiterpene decreased the expression of Beclin-1, LC3 and p62/SQSTM1 in glioblastoma cells. The gene discussed is SQSTM1; the disease is glioblastoma.