STAT3 and cancer: Considering the well-known key role of the STAT3 cascade in the control of cell migration, cancer cell survival and apoptosis inhibition, especially through the activation by phosphorylation at tyrosine 705, namely pSTAT3(Tyr705) [37,48], we studied the modulation of this cascade as a possible chemopreventive mechanism of β-caryophyllene towards CSC.