At last, IL-8 is a chemotaxis cytokine, which has been reported to be upregulated in poor prognosis triple-negative breast cancers; it also promoted migration of the MDA-MB-231 cells via PI3K-Akt and MAPK cascades and induced cell cycle arrest in the S phase [94,95]. The gene discussed is CXCL8; the disease is triple-negative breast carcinoma.