During hyperoxic conditions, as occurring in COVID-19, CY1B1, whose production is enhanced by TNF-α, buffers ROS by forming oxidized adducts in DNA [94]; therefore, COVID-19 is a condition where the role of CYP1B1 as a key regulator of ROS as signaling molecules is impaired, due to TNF-α. Here, TNF is linked to COVID-19.