Immunoregulatory factor TIM3 may regulate the proliferation and invasion of lung adenocarcinoma cells through signaling pathways (such as cytolytic activity), further regulate the immune microenvironment of lung adenocarcinoma, and has a certain risk correlation with drug resistance of tumor cells, which indirectly affects the survival and prognosis of lung adenocarcinoma patients to a certain extent. The gene discussed is HAVCR2; the disease is neoplasm.