TARDBP and amyotrophic lateral sclerosis: In particular, α-synuclein is overexpressed in PD platelets [30,66] and detected in less dense microvesicles [30]; amyloid β peptide fibrils are stored in dense platelet microvesicles in AD [29]; higher levels of TDP-43 protein [33] and lower serotonin level [34,38] were detected in ALS platelets.