Modulation of Panx1, either pharmacologically with probenecid or via genetic deletion, was evaluated by Aquilino et al., who found that seizure activity was suppressed by both methods across all epilepsy models in mice (injection of pentylenetetrazol, acute electrical kindling of the hippocampus and exposure to 4-aminopyridine) [157]. This evidence concerns the gene PANX1 and epilepsy.