Bortezomib (20S particle inhibitor) is the first proteasome inhibitor approved by FDA for the treatment of MM, MCL, WM, non-small-cell lung cancer (NSCLC), and pancreatic cancer [92]; additionally, it is now in clinical trials for DLBCL in combination with R-CHOP and for newly diagnosed or relapsed and refractory MM-in combination therapy with dexamethasone (NCT01965977; NCT03129828; NCT05052970; NCT04140162; NCT04717700; NCT05218603; NCT03896737; NCT03733691; NCT03110562). The gene discussed is DDIT3; the disease is non-small cell lung carcinoma.