NFKB1 and neoplasm: IT-901 induces anti-tumor effects by a dose-dependent increase in mitochondrial reactive oxygen species (ROS) along with a reduction of NF-κB-dependent transcription of genes encoding for Cytochrome c oxidase assembly subunit 2 (SCO2), ATP-synthase, and ATP5A1, as well as ROS scavenger, catalase (CAT), mitochondrial membrane potential, maximal Oxygen Consumption Rate (OCR), and ATP production [182].