A subsequent study by the same laboratory demonstrated that the sensitivity of a subset of ABC tumors to ibrutinib depends on the BTK-dependent assembly of a supercomplex formed by the MYD88, TLR9, and BCR (My-T-BCR) signalosomes, which co-localize with the mTOR signaling complex on endo-lysosomes to coordinate survival signaling by the NF-κB and mTOR pathways [95]. The gene discussed is MTOR; the disease is aneurysmal bone cyst.