Furthermore, SHK was shown to inhibit the expression of inflammatory proteins such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), Interleukin-6 (IL-6), and TNFα and revert the malignant phenotype by suppressing cancer cell proliferation via NF-κB blockade in both CRC cells and mouse models [107]. Here, NOS2 is linked to colorectal carcinoma.