DIABLO and colorectal carcinoma: At least two other small-molecule SMAC mimetics have entered phase II trials in oncology: LCL161, an orally available compound which has been tested as a monotherapy and in combination with chemotherapy in patients with high-grade serous ovarian carcinoma (HGSOC), breast carcinoma, HNSCC, and relapsed or refractory MM; and birinapant (TL32711), which was tested in combination with keytruda (pembrolizumab) in patients with microsatellite stable (MSS) colorectal carcinoma (CRC) (NCT01955434; NCT01240655; NCT01617668; NCT02890069; NCT04553692; NCT02587962; NCT01486784; NCT00993239).