ASTX660 is one of non-peptidomimetic small-molecule inhibitors of c-IAP1/2 and X-linked inhibitor of apoptosis protein (XIAP); it is currently in phase I/II trials in patients with advanced-stage solid tumors and NHLs and is also in a phase II study in patients with peripheral and cutaneous T-cell lymphoma (TCL) (NCT05082259; NCT02503423; NCT04155580; NCT04362007; NCT05403450). Here, XIAP is linked to primary cutaneous T-cell non-Hodgkin lymphoma.