UBA1 and cancer: Notably, other E1 inhibitors like TAK-243, TAS-4464 and ML-792 targeting ubiquitin-like modifier-activating enzyme 1 (UBA1), NAE and SUMO E1 activating enzyme, respectively, have been investigated in several cancer models, both in vitro and in vivo, and encouraging results have been reported [159,160,161,162].