In RVLM, we reported previously that increases in the protein expression of NADPH oxidase subunits [43], and decreases in the expression of antioxidants [46], contribute to oxidative stress that results in sympathoexcitation and hypertension in spontaneously hypertensive rats and normotensive animals treated with angiotensin II (Ang II). The gene discussed is FMO5; the disease is hypertensive disorder.