Mitochondrial disease-causing mutations were found in thirteen small ribosomal subunit mitoribosomal proteins (MRPS1, MRPS2, MRPS6, MRPS7, MRPS9, MRPS11, MRPS14, MRPS16; MRPS22, MRPS23, MRPS25, MRPS34, MRPS39) and four large ribosomal mitochondrial proteins (MRPL3, MRPL12, MRPL24, MRPL44) [41]. This evidence concerns the gene MRPS22 and mitochondrial disease.