NOTCH1 and acute lymphoblastic leukemia: According to the COSMIC database (cancer.sanger.ac.uk accessed on august 6, 2022), CEM cells harbors mutations in NOTCH1, FLT3, and KRAS, while MOLT-4 in PTEN, NOTCH1, and NRAS, among many others, interfering with multiple key signaling pathways critical in ALL [41].