In mice on a pure 129 SV background, sucrose/fructose supplementation has been shown to induce fatty liver accompanied by the induction of the hepatic expression of Scd1 and other lipogenic proteins in Srebp-1c-knockout mice, but not in Scd1-knockout mice [42], indicating that the importance of the expression of Scd1 for the development of sucrose/fructose-induced fatty liver. The gene discussed is SCD; the disease is fatty liver disease.