Since increased hepatic PPARγ2 leads to the development of fatty liver [50], the higher expression of Pparγ2 in the liver of male PPARα−/− mice, which show the compensatory expression of PPARγ, is associated with an increase in the liver TG level of male PPARα−/− mice, as previously reported [31,44,51]. The gene discussed is PPARA; the disease is Hepatic steatosis.