More recently, an inhalation delivered aerosolized LNP-encapsulated mRNA encoding for the protein DNAI1 demonstrated effective delivery of DNAI1 mRNA into the lower airways and the effective enhancement of ciliary beat frequency in an inducible Dnaic1 knockout mouse model for primary ciliary dyskinesia (PCD) [99]. This evidence concerns the gene DNAI1 and primary ciliary dyskinesia.